The Sczepanski Research Group combines expertise in chemical biology, nucleic acid chemistry, molecular biology, and directed evolution, in order to develop novel tools for studying, monitoring, and modulating nucleic acid-related biological processes. We are currently involved in the following major areas:

• Use of chemical biology approaches to investigate the relationships between chromatin structure and DNA modifications.
• Engineering L-DNA nanodevices and circuitry capable of analyzing and manipulating molecular information in living systems.
• Development of nucleic acid-based affinity reagents and catalysts for practical biomedical applications.
• Investigating how oligonucleotides of opposite stereochemistry interact, both in terms of molecular recognition and catalysis.